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The Best Anti-aging Serums for Men

Written by: Dr. Leslie Baumann

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Time to read 4 min

As men grow older, attaining and preserving youthful-looking skin becomes increasingly difficult. Skin loses elasticity, glow, and smoothness over time while wrinkles, spots and sagging slowly manifest no matter how gracefully we aim to age. But incorporating targeted anti-aging skincare can help stall the hands of time.

Utilizing a specialized serum packed with age-defying ingredients is one of the most effective methods to tackle common mature male skin concerns. Unlike thick creams, lightweight serums feature concentrated doses of active ingredients that rapidly penetrate the skin barrier to impart benefits.

To help you look as young as you feel, we have put together the top 10 anti-aging serums for men.

Make sure to take our skin type quiz to make sure you only buy the right products for your skin type. Nothing feels worse than wasting money on the wrong products!

best anti-aging serums for men

The Best Anti-Aging Serums For Men

La Roche-Posay Redermic Anti-aging Treatment Intensive

This intensive anti-aging serum contains a stabilized form of retinol for deep wrinkle correction. It's great for targeting fine lines, wrinkles, dark spots and uneven texture. The formula is ideal for men with oily or irregularly pigmented skin. Use this serum only at night. During the day, be sure to apply sunscreen to protect newly surfaced skin cells.

Revision Skincare C+ Correcting Complex

Combat the fading of your glowing skin with this serum loaded with peptides, antioxidants and tons of Vitamin C. It helps build collagen, fade dark spots and improve skin tone and texture. The soothing formula is ideal for men with sensitive or dry skin. For optimal results, use twice daily alone or pair with a retinol cream at night.

Zerafite Wrinkle Defense Barrier Cream

The rich moisturizing properties of Zerafite come from active ingredients including glycerin, ceramides, cholesterol, and a number of beneficial fatty acids to shield vulnerable skin from harmful environmental aggressors. Fine lines, wrinkles and free radical damage that accumulate due to pollution and other external factors can be minimized over time with this trusted product.

Alastin Restorative Skin Complex

The potent peptide complex in this serum helps support the skin's elasticity and resilience for a firmer, smoother and more youthful appearance. Its formula boosts hydration levels and absorbs quickly without leaving behind any greasy residue. It's ideal for men who want anti-aging benefits but cannot tolerate traditional retinol treatments.

Defenage 8-in-1 Bioserum

This intelligent “Swiss Army knife” of a serum wields a blended arsenal of antioxidants, texture-refining alpha hydroxy acids, patented peptides and other supporting molecules to simultaneously tackle wrinkles, stubborn spots, hyperpigmentation, and sun-damage in one comprehensive formula. Your skin will feel renewed in just a few weeks. What's more, this product is great for sensitive skin types and easy to tolerate, so long as you are not allergic to niacinamide.

Medature Encapsulated Retinol Serum

This gentle yet effective anti-aging serum uses an innovative encapsulated retinol delivery system to gradually release the active ingredients to minimize irritation and dryness. It's suitable for all skin types including sensitive and helps smooth away fine lines while refining skin texture, shrinking pores and fading dark spots. If redness is an issue for you, introduce this product slowly at first - every third day - until you become used to it. Once your skin is comfortable enough with the use of retinoids, you can start using this product daily.

Plated SkinScience Intense Serum

Protect your skin's boyish glow with this cutting-edge serum. It contains exosomes - tiny, naturally occurring messenger structures - to signal your skin cells to ramp up collagen production. To get the most out of this product, I recommend using it alongside vitamin C and/or retinoids. Most men notice a visible difference within 2 weeks when used daily.

SkinCeuticals C+ AHA

The Vitamin C and glycolic acid duo packed into this breakthrough serum delivers both short and long term brightening, exfoliating and collagen boosting results specifically tailored for men with resistant skin types that can tolerate its uniquely low pH formulations. While some positive effects may appear within weeks, the full scope of benefits often unfold gradually over a 3-6 month period of consistent use, ultimately combatting dulling tone and early wrinkling. Use caution when combining with retinol, as both ingredients are highly effective exfoliants that could potentially over-dry the skin if applied simultaneously.

Sente Dermal Repair Cream

Multiple hydrating ingredients like glycerin, heparan sulfate and glucosamine fill the skin with vital moisture while smoothing out mature lines. Supported by a combination of Vitamin E and other anti-aging ingredients, this product bolsters collagen and defends against environmental stressors over time. I recommend using this product as part of your AM skin care routine. At night, use this product alongside a retinoid if you can tolerate retinoids.

Neocutis Bio Gel Firm Moisturizing Hydrogel

One of my favorite anti-aging serums for men - this uniquely lightweight serum leverages an optimal formulation of skin-structure-supporting peptides, antiaging growth factors and hyaluronic acid aiming to improve sagging mature skin and wrinkled texture by targeting, filling and preventing volume loss for visibly denser, renewed firmness. This product has zero estrogenic side-effects and is fragrance free, meaning it is perfectly tailored for male use.

We hope this list of anti-aging serums has given you more confidence that the fate of your face is still in your hands. A good anti-aging product can make all the difference in the way your skin matures. I hope you'll take our quiz by clicking the button just below here; doing so will get you a free recommendation for a complete skin care regimen that you can choose to customize to your preferences.

Thanks for checking out this blog!

Level up your skin care knowledge with medical advice from dermatologists

Best References on Anti-aging ingredients and products:

  1. Baumann L. Antiaging Ingredients in Ch. 37 of Baumann's Cosmetic Dermatology Ed 3. (McGraw Hill 2022)
  2. Baumann, L. Ch.  Cosmeceuticals and cosmetic Ingredients (McGraw Hill 2015)